For years, independent practices have operated at a distinct financial disadvantage compared to hospital-based departments. Managing provider enrollment and credentialing for a private clinic often feels like an uphill battle when hospitals command significantly higher reimbursement for the exact same services. However, a major regulatory shift is about to change the math for independent groups nationwide.
The Trend: CMS Signals Continued Interest in Site-Neutral Expansion
CMS has signaled continued interest in expanding site-neutral payment policies, including for drug administration services, but no CY 2026 final rule has implemented a 40–60% reduction. The policy focus remains centered on services furnished in off-campus hospital outpatient departments (HOPDs), including chemotherapy, immunotherapy, and related injections.
OPPS rates for drug administration can be 40–60% higher than PFS rates, which is why site-neutral proposals would significantly reduce HOPD reimbursement if adopted. If adopted, site-neutral policies would reduce the financial incentive for hospitals to acquire independent practices simply to capture higher facility fees.
The Veracity Take: Your New Leverage in Payer Negotiations
This policy direction is more than just a Medicare update; it is a powerful weapon for your commercial contract negotiations. For too long, payers have justified lower rates for independent clinics by pointing to the "comprehensive" nature of hospital systems. CMS has repeatedly indicated that certain services may be appropriate for site-neutral payment, particularly when furnished in off-campus HOPDs, and that keeps pressure on the "hospital premium."

Independent practices must use this data to demand commercial rate parity. If a hospital-owned site down the street is now being capped at the same Medicare rate as your clinic, there is no logical reason for a commercial payer to continue paying that hospital a 200% premium over your fee schedule. This is the moment to audit your payer mix and identify which contracts are ripe for a "parity-based" renegotiation.
The administrative burden of maintaining these contracts is high, but the cost of silence is higher. You can read more about why payers deny claims on day one and how to prevent it to ensure your revenue cycle is protected during these transitions.
Actionable Steps for Independent Clinics
- Audit Your Specialty Mix: Identify drug administration codes within your practice that would be affected if CMS expands site-neutral policies in 2026 rulemaking.
- Benchmark Your Rates: Compare your current commercial reimbursement to the local HOPD "facility-plus-professional" total.
- Initiate "Parity" Conversations: Use the ongoing site-neutral policy direction as a baseline to argue that the market value for these services is under increasing scrutiny.
- Review Enrollment Data: Ensure all locations and providers are correctly classified to avoid being swept into incorrect "facility" designations.
For detailed official guidance on current Medicare payment policy, refer to CMS.
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The Bottom Line
Site-neutrality remains a major policy direction heading into 2026, and independent practices that act now will be better positioned if CMS expands site-neutral policies in 2026 rulemaking. That preparation is what will help you compete in a more transparent, competitive healthcare market.
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